You’ve heard the dramatic weight loss stories. Semaglutide, the active ingredient in Ozempic and Wegovy, can help people lose 15 percent of their body weight. Tirzepatide, sold under the brand names Mounjaro and Zepbound, may be even more effective at shedding pounds.
There’s no such thing as a miracle cure for weight loss, but the latest obesity drugs seem to come pretty close. People who take Ozempic or other weekly shots belonging to a class known as GLP-1 agonists, after the gut hormone they mimic, can lose a fifth or more of their body weight in a year. Incessant “food noise” fueling the urge to eat suddenly goes silent.
For centuries, Burg Ockenfels was home to medieval knights angling to control traffic along the Rhine River. Today the stone castle flaunts two round towers, a row of Renaissance-style statues and a courtyard that looks out over hills and farms.
When patients start on the latest obesity drugs, they find that their food cravings drop away, and then the pounds do too. But when patients go off the drugs, the gears shift into reverse: The food cravings creep back, and then the pounds do too.
A year ago, Google said that it believed AI was the future of search. That future is apparently here: Google is starting to roll out “AI Overviews,” previously known as the Search Generative Experience, or SGE, to users in the US and soon around the world.
America’s independent bookstores may look like the tattered, provincial shops of a bygone era—holding onto their existence by the slimmest thread. And booksellers may appear genial and absent-minded, like characters out of Dickens. But in reality, they’re the marketing geniuses of our time.
When scientists first created the class of drugs that includes Ozempic, they told a tidy story about how the medications would work: The gut releases a hormone called GLP-1 that signals you’re full, so a drug that mimics GLP-1 could do the exact same thing, helping people eat less and lose weight.
In 2002, the FDA approved Suboxone, a new medication to treat opioid use disorder. Suboxone is a compound of two drugs that decreases one’s cravings for opioids while blocking their effects.
It was when I was researching a story on that I realized there truly was no escape from the influencer industry. If business bros with corporate jobs in tech and finance — stable, high-paying careers with cushy benefits! — felt the need to supplement their status (and possibly their income) by becoming influencers, what hope was there for the rest of us?
Allison is an actress. When we meet up for coffee — she has an almond-milk cortado — in midtown, something’s different about her, but I’m not sure what. She looks like an Instagram version of herself but in real life. It turns out she’s down about ten pounds and happy about it. “Somebody once told me I had a size-zero personality, and they assumed that I was thinner than I was,” she tells me. “We don’t talk about it, but everybody knows it. Thin is power.”
