In July 1990, President George H. W. Bush issued a presidential proclamation to mark the dawn of a new and exciting era of neuroscience. The ’90s, Bush said, would be the “decade of the brain”—a 10-year scientific blitz that promised to render the human brain, “one of the most magnificent—and mysterious—wonders of creation,” a bit less mysterious.
When scientists first created the class of drugs that includes Ozempic, they told a tidy story about how the medications would work: The gut releases a hormone called GLP-1 that signals you’re full, so a drug that mimics GLP-1 could do the exact same thing, helping people eat less and lose weight.