There’s no such thing as a miracle cure for weight loss, but the latest obesity drugs seem to come pretty close. People who take Ozempic or other weekly shots belonging to a class known as GLP-1 agonists, after the gut hormone they mimic, can lose a fifth or more of their body weight in a year. Incessant “food noise” fueling the urge to eat suddenly goes silent.
For centuries, Burg Ockenfels was home to medieval knights angling to control traffic along the Rhine River. Today the stone castle flaunts two round towers, a row of Renaissance-style statues and a courtyard that looks out over hills and farms.
When scientists first created the class of drugs that includes Ozempic, they told a tidy story about how the medications would work: The gut releases a hormone called GLP-1 that signals you’re full, so a drug that mimics GLP-1 could do the exact same thing, helping people eat less and lose weight.
In 2002, the FDA approved Suboxone, a new medication to treat opioid use disorder. Suboxone is a compound of two drugs that decreases one’s cravings for opioids while blocking their effects.
Thomé de Gamond’s plans for an underwater tunnel between England and France, produced for the World Exposition of 1867. The yellow circles, top left, represent an enormous spiral ramp allowing access to the tunnel from an international artificial island on the Varne sandbank — Source.
Two weeks in a row, ChatGPT botched my grocery list. I thought that I had found a really solid, practical use for AI—automating one of my least favorite Sunday chores—but the bot turned out to be pretty darn bad at it.
